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Introduction to Methylone

Methylone (bk-MDMA), chemically known as 3,4-methylenedioxy-N-methylcathinone, is a synthetic cathinone belonging to the phenethylamine and amphetamine classes of compounds . It is the beta-keto analogue of MDMA, distinguished by an oxygen atom at the benzylic position of the propane sidechain . First synthesized in the mid-1990s by Jacob and Shulgin as a potential treatment for Parkinson’s disease and depression, methylone has since become one of the most extensively studied synthetic cathinones in forensic and toxicological research .

Methylone is reported under various names including bk-MDMA, MDMC, and M1, with street names such as “Ease,” “Explosion,” and “Impact” . As a research chemical, it is primarily utilized as a certified reference material for forensic and analytical applications, including method development and quality control . At 4mmcchems, we supply premium-grade Methylone to researchers and professionals worldwide, with a focus on fast, discreet shipping across Europe.

Product Specifications

Product Name: Methylone (bk-MDMA)

Synonyms: 3,4-Methylenedioxy-N-methylcathinone, MDMC, bk-MDMA, M1

CAS Number: 186028-79-5 (base, racemic); 186028-80-8 (hydrochloride salt)

Molecular Formula: C₁₁H₁₃NO₃

Molecular Weight: 207.23 g/mol

Purity: ≥ 98% (verified by third-party HPLC testing)

Form: White or lightly coloured crystalline powder

Storage: -20°C for long-term stability

Availability: In stock, ready for immediate dispatch

Chemical Properties and Mechanism of Action

Methylone acts as a non-selective substrate at the serotonin transporter (SERT), dopamine transporter (DAT), and norepinephrine transporter (NET) . Unlike pure reuptake inhibitors, methylone is transported into the presynaptic neuron and induces the release of monoamine neurotransmitters through transporter-mediated efflux .

Key Pharmacological Data

• Mechanism: Nonselective substrate for plasma membrane monoamine transporters, similar to MDMA in potency and selectivity

• SERT Inhibition (IC₅₀): 5.8 µM – approximately threefold less potent than MDMA at inhibiting serotonin uptake

• DAT Inhibition (IC₅₀): 0.82 µM – similar in potency to MDMA at catecholamine transporters

• Dopamine and Serotonin Release: In vivo microdialysis demonstrates dose-related increases in extracellular dopamine and serotonin, with greater magnitude of effect on serotonin

• Chiral Properties: Contains a chiral centre at the C-2 carbon of the propane sidechain; S-form is thought to be more potent than R-form

Receptor Binding Profile

Research indicates that the DAT binding affinity of methylone is 2.4 times higher than that of MDMA, though the potency of actual DAT-mediated release appears much lower than its non-keto analogue . Methylone shows potential for abuse liability, with animal studies demonstrating that it functions as a reinforcer in self-administration paradigms .

Why Choose 4mmcchems?

1. Uncompromising Quality

We source our Methylone from certified manufacturers with strict adherence to Good Manufacturing Practice (GMP) guidelines. Every batch undergoes independent HPLC and GC-MS testing to guarantee purity and potency, meeting the ≥98% purity threshold required for analytical reference materials .

2. Discreet and Secure Packaging

Your privacy is paramount. All orders are shipped in plain, unbranded packaging with no external markings indicating contents. Tamper-evident seals ensure security throughout transit.

3. Worldwide Shipping with European Focus

4mmcchems operates a robust global logistics network. We offer fast, reliable shipping to customers worldwide, with a particular emphasis on European markets:

• European Shipping: Methylone is subject to control across numerous European countries. It was added to Sweden’s narcotics schedule in October 2010 and is illegal in the United Kingdom following the April 2010 revision of the Misuse of Drugs Act . We have optimized shipping routes to ensure timely delivery to all EU member states, the UK, Switzerland, and more.

• Fast Transit Times: Typical delivery to European destinations ranges from 3 to 7 business days.

• Tracking Provided: Every order comes with a tracking number for real-time shipment monitoring.

4. Competitive Pricing and Bulk Discounts

We offer tiered pricing for bulk orders, making 4mmcchems the cost-effective choice for large-scale research projects. Contact our sales team for custom quotes.

5. Responsive Customer Support

Our knowledgeable team is available to answer queries regarding product specifications, shipping, and order status. We prioritize clear and prompt communication.

Safety and Regulatory Information

Methylone is a controlled substance in many jurisdictions globally. The World Health Organization’s Expert Committee on Drug Dependence recommended that methylone be placed in Schedule II of the 1971 Convention on Psychotropic Substances . In the United States, methylone was listed as a Schedule I controlled substance under the Controlled Substances Act in April 2013 .

Methylone has been associated with numerous adverse events including tachycardia, hypertension, paranoia, anxiety, bruxism, and muscle tension . Serious adverse events including seizures, hyponatremia, and rhabdomyolysis have been reported . Fatal intoxications have been documented, with peripheral blood methylone concentrations in excess of 0.5 mg/L potentially resulting in death due to toxic properties including elevated body temperature and sympathomimetic-like symptoms .

Important Considerations for Researchers:

• Controlled Status: Methylone is controlled in many countries, including Germany (subject to the Narcotic Act, with a permit under Section 3 BtMG mandatory for ordering) . It is the customer’s responsibility to verify the legal status of this product in their jurisdiction before placing an order.

• Research Use Only: This product is intended for research, forensic, and analytical applications only. Not for human or veterinary use .

• Handling Precautions: Standard laboratory safety protocols should be followed when handling this compound. Methylone is classified as acute toxic (H302 – Harmful if swallowed; H336 – May cause drowsiness or dizziness) .

Shipping Information: Worldwide Delivery

4mmcchems is committed to making our products accessible globally. We ship to all major regions, including:

• Europe: All EU member states, UK, Switzerland, Norway, and more.

• North America: USA, Canada, Mexico.

• Asia: Japan, South Korea, Singapore, China, India, and others.

• Australia & Oceania

• South America

• Middle East & Africa

Shipping Methods:

• Standard Air Mail (7-21 days, tracking available)

• Express Courier (3-7 days, fully tracked, signature required)

Customs and Duties: Customers are responsible for any customs duties or import taxes applicable in their country. We provide all necessary documentation to facilitate smooth customs clearance, subject to local regulations.

How to Order

1. Browse Our Catalog: Select Methylone and add to cart.

2. Checkout: Fill in your shipping details and choose your preferred payment method.

3. Payment: We accept cryptocurrencies and bank transfers for secure transactions.

4. Confirmation: Receive an order confirmation with tracking details upon dispatch.

Frequently Asked Questions

Q: What is Methylone used for in research?

A: Methylone is used as an analytical reference standard for forensic and toxicological applications, including GC-MS and LC-MS testing methods, transporter binding assays, and neuropharmacological studies .

Q: Is Methylone legal to purchase?

A: Methylone is a controlled substance in many countries, including the US (Schedule I) and numerous European nations . It is the customer’s responsibility to verify the legal status of this product in their jurisdiction before placing an order.

Q: How should Methylone be stored?

A: Store at -20°C for long-term stability. Protect from light and moisture. Methylone hydrochloride is a white or lightly coloured powder that is readily soluble in water .

Q: What if my order is seized by customs?

A: While we take every precaution to ensure successful delivery, we cannot guarantee customs clearance in all countries, especially given the controls on methylone. Please refer to our shipping policy for more details.